Edouard Drouhet

From:
Viviani MA. Obituary: Edouard Drouhet. Mycopathologia, Volume 148, Number 3, 1 March 1999 , pp. 111-112(2).
Viviani MA. In memory of Edouard Drouhet. Mycology Newsletter. Vol. 1, 2000, pp. 4-5(2).

Edouard Drouhet, a key figure in the field of Medical Mycology during the last century, died on January 1, 2000, in Paris. He was born in Barlad, Romania, in 1919 from a family of French descent. His grandfather was a medical doctor born in Blaye, in the Gironda region of France. Prof. Drouhet was very proud of his French ancestry. In his writing he recalls with great emotion a visit to Blaye made in 1997, together with Marianna Viviani, following a meeting of the French Society of Medical Mycology held in Arcachon. That day he discovered in the cemetery of this small town the grave of his great-grandmother. In Romania, Drouhet began his studies in medicine and in 1944 he obtained his degree in medicine. Twelve years later, he also obtained a degree in medicine at the University of Paris. Soon after the end of the Second World War, he moved to Paris, together with his wife Victoria having earned a grant from the French Government. In 1946, he joined Joseph Magrou, a physician and botanist and the director of the Service de Physiologie Végétale-Mycologie of the Pasteur Institute.

Prof. Drouhet decided to settle in Paris and in 1948 he was appointed as “attaché de recherches” at the Centre National de la Recherche Scientifique (CNRS) under the direction of Prof. André Lwoff, Noble Prize winner for Medicine and Physiology. In Paris, he specialized in Microbiology at the Pasteur Institute (1947), in Serology at the Fournier Institute (1948), and in 1954 he definitely definitely joined the Pasteur Institute as “Chef de Laboratoire” in the Service of Prof. Magrou. There he met Gabriel Segretain and François Mariat and the mutual understanding of the three scientists gave rise to the team that played a leading role in the development of Medical Mycology in France and in Europe. Under the influence of Drouhet, the Service modified the direction of its research programs turning from botany to Medical Mycology. It focused on human and animal pathogenic fungi and on the study of effective antifungal treatments for mycotic diseases.

In 1953, Prof. Drouhet together with Drs. Segretain and Mariat founded the “Cours supérieur de mycologie médicale” at the Pasteur Institute, a post-graduate Course that in 48 years trained about a thousand mycologists from France and other European and extra-European countries. In a short period of time the Course gained importance representing probably the most important result of the teaching activities of Drouhet brought indefatigably, to France and overseas, until recent years. In 1953, Drouhet was also a cofounder of the International Society of Human and Animal Mycology (ISHAM) and in 1956, together with Segretain and Mariat, he founded the Société Française de Mycologie Médicale. These three Institutions promoted and significantly contributed to the great development of the Medical Mycology in the ensuing years. Forty years later, Prof. Drouhet supported with great enthusiasm the creation of the European Confederation of Medical Mycology. He was convinced that future developments in European Medical Mycology would be achieved through the creation of networks on a continental level, dealing with epidemiological studies, on the standardization of diagnostic procedures, on educational programs and in training.

In the photo: Edouard Drouhet, François Mariat and Gabriel Segretain (left to right on the roof of the Laboratoire de Mycologie, Institut Pasteur, Paris, 1954, with the Eiffel Tower in the background).

In 1972, Drouhet was given the rank of Professor at the Pasteur Institute and there he established the Centre National de Référence des Mycoses et des Antifongiques in Paris. In 1981, he succeeded Gabriel Segretain as Director of the “Unité de Mycologie” of the Pasteur Institute, a position that he held until his retirement in 1987. After his retirement, Drouhet actively participated in the scientific community’s life and from 1990 he served as Chief Editor for the «Journal de Mycologie Médicale», which had replaced the «Bulletin de la Société Française de Mycologie Médicale». Through his guidance, the journal became one of the most authoritative in the field of Medical Mycology.
Since its beginning, Edouard Drouhet´s research work was characterized by its innovative nature. Before his era, the Pasteur Institute´s studies on fungal pathogens were restricted to the field of botany. Drouhet resolutely initiated the study of human and animal fungal pathogens, carrying out studies on the physiological and biochemical activities of these fungi in relation to their growth, morphogenesis and pathogenicity, and developing techniques for the rapid diagnosis of fungal diseases. Drouhet greatly contributed to a better knowledge of diseases due to opportunistic fungi. He highlighted new aspects of Candida albicans infections developing studies in premature infants and children and discovering in 1980 a new cutaneous, ocular and osteoarticular septicemic syndrome in young heroin addicts. In 1953, he was the first to test in France such new antifungals as nystatin and amphotericin B, defining dosage and therapeutic indications and investigating their mechanisms of action.

In the photo: Professors Drouhet, Mariat and Segretain: the elder statesmen of the Mycology Unit of the Pasteur Institute at the XIII Congress of ISHAM in Salsomaggiore, 1997. From left to right: Edouard Drouhet, Mrs Segretain, Gabriel Segretain, François Mariat, Mrs Mariat (courtesy E. Gueho).

A constant interest of Drouhet´s researches was the host´s immunological response to fungal infections. By 1950, he had already shown the role of a capsular polysaccharide (glucuronoxylomannan) of Cryptococcus neoformans in fungal virulence, and identified it as the cause of the immunological paralysis during cryptococcosis. Finally, he prepared standardized fungal antigens for the qualitative and quantitative study of serum antibodies in patients with deep-seated mycoses. On 5 June 1999, at the ECMM Congress in Dresden, Edouard Drouhet took his leave from the scientific community. He was very ill and suffering a great deal, but he forced himself to fulfil his commitment and gave a remarkable lecture on Emmonsia pasteuriana, the new species he had identified and named to commemorate his beloved Pasteur. The audience witnessed a great lesson of scientific discipline and style and acknowledged Drouhet as a world class medical mycologist.

Maria Anna Viviani